Gisela P. Concepcion, Ph.D.
Professor 
Academician of the National Academy of Science and Technology (NAST)


Education:
Ph.D. Chemistry
University of the Philippines, Diliman 

Research Interests: 
Marine Natural Products, Biochemistry, Development of Bioscreening Methods 

Selected Publications:
  • Torres JP, Lin Z, Fenton DS, Leavitt LU, Niu C, Lam P-Y, Robes JM, Pterson RT, Concepcion GP, Haygood MG, Olivera BM, Schmidt EW. 2020. Boholamide A, an APD-Class, Hypoxia-Selective Cyclodepsipeptide. Journal of Natural Products. Article in Press.
  • Miller BW, Torres JP, Flores MS, FOrteza I, Rosenber G, Haygood MG, Schmidt EW, Concepcion GP. 2020. Synergistic anti-methicillin-resistant Staphylococcus aureus (MRSA) activity and absolute stereochemistry of 7,8-dideoxygriseorhodin C. Journal of Antibiotics. Article in Press
  • Tun JO, Salvador-Reyes LA, Velarde MC, Saito N, Suwanborirux K, Concepcion GP. (2019). Synergistic cytotoxicity of Renieramycin M and Doxorubicin in MCF-7 breast cancer cells. Marine Drugs, 17(9):536.
  • Shipway RJ, Rosenber G, Concepcion GP, Haygood MG, Savrda C, Distel DL. 2019. Shipworm bioerosion of lithic substrates in a freshwater setting, Abatan River, Philippines: Ichnologic, paleoenvironmental and biogeomorphical implications. PLoS ONE, 14(10):e0224551.
  • Shipway JR, Altamia MA, Rosenberg G, Concepcion GP, Haygood MG, Distel DL. 2019. Tamilokus mabinia, a new, anatomically divergent genus and species of wood-boring bivalve from the Philippines. PeerJ, 7:e6256a
  • Shipway RJ, Altamia MA, Rosenberg G, Concepcion GP, Haygood MG, Distel DL. (2019). A rock-boring and rock-ingesting freshwater bivalve (shipworm) from the Philippines. Proc Biol Sci., 286(1905):20190434
  • Lacerna NM, Miller BW, Lim AL, Tun JO, Robes JMD, Cleofas MJB, Lin Z, Salvador-Reyes LA, Haygood MG, Schmidt EW, Concepcion GP. 2019. Mindapyrroles A−C, pyoluteorin analogues from a shipworm-associated bacterium. J. Nat. Prod. 82:1024−1028
  • Altamia MA, Shipway JR, Concepcion GP, Haygood MG, Distel DL. 2019. Thiosocius teredinicola gen. nov., sp. nov., a sulfur-oxidizing chemolithoautotrophic endosymbiont cultivated from the gills of the giant shipworm, Kuphus polythalamius. Int J Syst Evol Microbiol 69(3):638-644.
  • Shipway JR, Altamia MA, Haga T, Velásquez M, Albano J, Dechavez R, Concepcion GP, Haygood MG, Distel DL. 2018. Observations on the life history and geographic range of the Giant Chemosymbiotic Shipworm Kuphus polythalamius (Bivalvia: Teredinidae). Biol Bull 235(3). DOI: 10.1086/700278
  • Belleza OJV, Tun JO, Concepcion GP, Villaraza AJL.  2018. On the inhibition of capsaicin response in dorsal root ganglion neurons by nobilamide B and analogues: a structure–activity relationship study. Med. Chem. Commun. 9:1673-1678. 
  • Azcuna M, Tun JO, Yap HT, Concepcion GP. 2018. Callyspongia samarensis (Porifera) extracts exhibit anticancer activity and induce bleaching in Porites cylindrica (Scleractinia). Chem Ecol 34(5):397–411.
  • Torres, JP, Tianero MD, Robes JD, Kwan JC, Biggs JS, Concepcion GP, Olivera BB, Haygood MG, Schmidta EW. 2017. Stenotrophomonas-like bacteria are widespread symbionts in cone snail venom ducts. Appl. Environ. Microbiol. 83(23), Article number e01418-17.
  • Saito N, Hirade H, Sirinmangkalakitti N, Concepcion GP, Hiramatsu A, Kubota M, Fujino A, Suwanborinux K. 2017. Chemistry of renieramycins. 16. Structure of 7-demethylrenieramycin o (= 14α-hydroxyrenieramycin s) from blue sponge, Xestospongia sp. Heterocycles 95(2):748–752.
  • Omaga CA, Carpio LD, Imperial JS, Daly NL, Gajewiak J, Flores MS, Espino SS, Christensen S, Filchakova OM, López-Vera E, Raghuraman S, Olivera BM, Concepcion GP. 2017. Structure and Biological Activity of a Turripeptide from Unedo gemmula bisaya Venom. Biochemistry 56(45):6051–6060.
  • Lin Z, Smith MD, Concepcion GP, Haygood MG, Olivera, BM, Light A, Schmidt EW. 2017. Modulating the serotonin receptor spectrum of Pulicatin natural products. J. Nat. Prod. 80(8):2360–2370.
  • Distel DL, Altamia MA, Lin Z, Shipway R, Han A, Forteza I, Atemano R, Peñaflor-Limbaco MG, Tebo AG, Dechaves R, Albano J, Rosenberg G, Concepcion GP, Schmidt EW, Haygood MG . 2017. Discovery of chemoautotrophic symbiosis in the giant shipworm Kuphus polythalamia (Bivalvia: Teredinidae) extends wooden-steps theory. Proc. Natl. Acad. Sci. U.S.A. 114(18), E3652–E3658.
  • Billones JB, Carrillo MCO, Organo VG, Sy JBA, Clavio NAB, Macalino SJY, Emnacen IA, Lee AP, Ko PL, and Concepcion GP. 2017. In silico discovery and in vitro activity of inhibitors against Mycobacterium tuberculosis 7,8-diaminopelargonic acid synthase (Mtb BioA). Drug Des. Dev. Ther. 11:563–574.
  • Barghi N, Concepcion GP, Olivera BM, Lluisma AO. 2016. Structural features of conopeptide genes inferred from partial sequences of the Conus tribblei genome. Mol Genet Genomics, 291(1):411–422.
  • Barghi N, Concepcion GP, Olivera BM, Lluisma AO. 2016. Characterization of the complete mitochondrial genome of Conus tribblei Walls, 1977. Mitochondrial DNA A Mapp Seq Anal. 27(6):4451-4452.
  • Billones, J. B., Carrillo, M. C. O., Organo, V. G., Macalino, S. J. Y., Sy, J. B. A., Emnacen, I. A., Clavio, N. A. B, & Concepcion, G. P. (2016). Toward antituberculosis drugs: In silico screening of synthetic compounds against Mycobacterium tuberculosis L,D-transpeptidase 2. Drug design, development and therapy, 10, 1147.  | Article |
  • Barghi, N., Concepcion, G. P., Olivera, B. M., & Lluisma, A. O. (2015). Characterization of the complete mitochondrial genome of Conus tribblei Walls, 1977. Mitochondrial DNA, 1-2. Article |
  • Barghi, N., Concepcion, G. P., Olivera, B. M., & Lluisma, A. O. (2015). Structural features of conopeptide genes inferred from partial sequences of the Conus tribblei genome. Molecular Genetics and Genomics, 1-12. Article |
  • Barghi, N., Concepcion, G. P., Olivera, B. M., & Lluisma, A. O. (2015). Comparison of the venom peptides and their expression in closely related Conus species: insights into adaptive post-speciation evolution of Conus exogenomes. Genome biology and evolution7(6), 1797-1814. Article |
  • Barghi, N., Concepcion, G. P., Olivera, B. M., & Lluisma, A. O. (2015). High conopeptide diversity in Conus tribblei revealed through analysis of venom duct transcriptome using two high-throughput sequencing platforms. Marine Biotechnology17(1), 81-98. Article |
  • Jacinto, M. P. V., Flores, M. S., Lin, Z., Concepcion, G. P., Schmidt, E. W., Faulkner, S., & Villaraza, A. J. L. (2014). Synthesis and bioactivity of nobilamide B. RSC Adv.4(71), 37609-37612. Article |
  • Arnaldo, F. B., Van Anthony, M. V., Konkalmatt, P. R., Owens, S. A., Asico, L. D., Jones, J. E., Yang, J., Lovett, D.L., Armando, I., Jose, P.A., & Concepcion, G. P. (2014). D1-like dopamine receptors downregulate Na+-K+-ATPase activity and increase cAMP production in the posterior gills of the blue crab Callinectes sapidusAmerican Journal of Physiology-Regulatory, Integrative and Comparative Physiology307(6), R634-R642. Article |
  • Imperial, J. S., Cabang, A. B., Song, J., Raghuraman, S., Gajewiak, J., Watkins, M. Showers-Corneli, P., Fedosov, A., Concepcion, G.P., Terlai, H., Teichert, R. W., & Olivera, B.M. (2014). A family of excitatory peptide toxins from venomous crassispirine snails: Using constellation pharmacology to assess bioactivity. Toxicon89, 45-54. Article |
  • Concepcion, G. P., Anas, A. R. J., & Azcuna, M. A. (2014). Anticancer compounds from Philippine marine organisms act on major pathways in cancer. Phil. Sci. Lett7, 207-227. Article |
  • Lin, Z., Zachariah, M. M., Marett, L., Hughen, R. W., Teichert, R. W., Concepcion, G. P., Haygood, M.G., Olivera, B.M., Light, A.R., & Schmidt, E. W. (2014). Griseorhodins D–F, neuroactive intermediates and end products of post-PKS tailoring modification in griseorhodin biosynthesis. Journal of natural products77(5), 1224-1230.Article |
  • Altamia, M. A., Wood, N., Fung, J. M., Dedrick, S., Linton, E. W., Concepcion, G. P., Haygood, M.G. & Distel, D. L. (2014). Genetic differentiation among isolates of Teredinibacter turnerae, a widely occurring intracellular endosymbiont of shipworms. Molecular ecology23(6), 1418-1432. Article |
  • Molina, J., Hazzouri, K. M., Nickrent, D., Geisler, M., Meyer, R. S., Pentony, M. M., Flowers, J.M., Pelser, P., Barcelona, J., Inovejas, S.A., Uy, I. Yuan, W., Wilkins, O., Michel, C., Locklear, S., Concepcion, G.P., & Purugganan, M.D. (2014). Possible loss of the chloroplast genome in the parasitic flowering plant Rafflesia lagascae (Rafflesiaceae). Molecular biology and evolution, msu051. Article |
  • Lin, Z., Koch, M., Pond, C. D., Mabeza, G., Seronay, R. A., Concepcion, G. P., Barrows, L.R., Olivera, B.M., & Schmidt, E. W. (2014). Structure and activity of lobophorins from a turrid mollusk-associated Streptomyces sp. The Journal of antibiotics67(1), 121-126. Article |
  • Lin, Z., Marett, L., Hughen, R. W., Flores, M., Forteza, I., Ammon, M. A., Concepcion, G.P., Espino, S., Olivera B.M., Rosenberg, G., Haygood, M. G., Light, A.R., & Schmidt, E.W. (2013). Neuroactive diol and acyloin metabolites from cone snail-associated bacteria. Bioorganic & medicinal chemistry letters,23(17), 4867-4869. Article |
  • Lin, Z., Torres, J. P., Ammon, M. A., Marett, L., Teichert, R. W., Reilly, C. A., Kwan, J.C., Highen, R.W., Flores, M., Tianero, M.D., Peraud, O., Cox, J.E., Light, A.R., Villaraza, A.J.L., Haygood, M.G., Concepcion, G.P., Olivera, B.M., & Schmidt, E.W. (2013). A bacterial source for mollusk pyrone polyketides. Chemistry & biology20(1), 73-81. Article |
  • Elshahawi, S. I., Trindade-Silva, A. E., Hanora, A., Han, A. W., Flores, M. S., Vizzoni, V., Schrago, C.G., Soares, C.A., Concepcion, G.P., Distel, D.L., Schmidt, E. W.,  Haygood, M. G. (2013). Boronated tartrolon antibiotic produced by symbiotic cellulose-degrading bacteria in shipworm gills. Proceedings of the National Academy of Sciences110(4), E295-E304. Article |
  • Betcher, M. A., Fung, J. M., Han, A. W., O’Connor, R., Seronay, R., Concepcion, G. P., Distel, D. L., & Haygood, M. G. (2012). Microbial distribution and abundance in the digestive system of five shipworm species (Bivalvia: Teredinidae). PLoS One7(9), e45309.Article |
  • Tatsukawa, M., Punzalan, L. L. C., Magpantay, H. D., Villasenor, I. M., Concepcion, G. P., Suwanborirux, K. Yokoya, M., Saito, N. (2012). Chemistry of renieramycins. Part 13: Isolation and structure of stabilized renieramycin type derivatives, renieramycins W–Y, from Philippine blue sponge Xestospongia sp., pretreated with potassium cyanide. Tetrahedron68(36), 7422-7428. Article |
  • Olivera, B. M., Watkins, M., Bandyopadhyay, P., Imperial, J. S., de la Cotera, E. P. H., Aguilar, M. B., Vera, E. L., Concepcion, G. P., & Lluisma, A. (2012). Adaptive radiation of venomous marine snail lineages and the accelerated evolution of venom peptide genes. Annals of the New York Academy of Sciences1267(1), 61-70. Article |
  • Lin, Z., Flores, M., Forteza, I., Henriksen, N. M., Concepcion, G. P., Rosenberg, G., Haygood, M. G., Olivera, B. M., Light, A. R., Cheatham, T. E., & Schmidt, E. W. (2012). Totopotensamides, polyketide–cyclic peptide hybrids from a mollusk-associated bacterium Streptomyces spJournal of natural products75(4), 644-649. Article |
  • Cabang, A. B., Imperial, J. S., Gajewiak, J., Watkins, M., Corneli, P. S., Olivera, B. M., & Concepcion, G. P. (2011). Characterization of a venom peptide from a crassispirid gastropod. Toxicon58(8), 672-680. Article |
  • Lin, Z., Reilly, C. A., Antemano, R., Hughen, R. W., Marett, L., Concepcion, G. P., Haygood, M. G., Olivera, B. M., Light, A.,  & Schmidt, E. W. (2011). Nobilamides A–H, long-acting transient receptor potential vanilloid-1 (TRPV1) antagonists from mollusk-associated bacteria. Journal of medicinal chemistry54(11), 3746-3755. Article |
  • Fedosov, A., Watkins, M., Heralde, F. M., Corneli, P. S., Concepcion, G. P., & Olivera, B. M. (2011). Phylogeny of the genus Turris: Correlating molecular data with radular anatomy and shell morphology. Molecular phylogenetics and evolution59(2), 263-270.Article |
  • Yu, P., Han, W., Van Anthony, M. V., Li, H., Arnaldo, F. B., Concepcion, G. P., Felder, R. A., Quinn, M. T., & Jose, P. A. (2011). Dopamine D 1 receptor-mediated inhibition of NADPH oxidase activity in human kidney cells occurs via protein kinase A–protein kinase C cross talk. Free Radical Biology and Medicine50(7), 832-840. Article |
  • Lin, Z., Antemano, R. R., Hughen, R. W., Tianero, M. D. B., Peraud, O., Haygood, M. G., Concepcion, G. P., Olivera, B. M., Light, A., & Schmidt, E. W. (2010). Pulicatins A− E, neuroactive thiazoline metabolites from cone snail-associated bacteria. Journal of natural products73(11), 1922-1926.Article |
  • Coombs, G. S., Yu, J., Canning, C. A., Veltri, C. A., Covey, T. M., Cheong, J. K., Utomo, V., Banerjee, N., Zhang, Z. H., Jadulco, R. C., Concepcion, G. P., Bugni, T. S., Harper, M. K., Mihalek, I., Jones, C. M., Ireland, C. M., & Virshup, D. M. (2010). WLS-dependent secretion of WNT3A requires Ser209 acylation and vacuolar acidification. Journal of cell science,123(19), 3357-3367.Article |
  • Tasdemir, D., Marshall, K. M., Mangalindan, G. C., Concepcion, G. P., Barrows, L. R., Harper, M. K., & Ireland, C. M. (2001). Deoxyamphimedine, a new pyridoacridine alkaloid from two tropical Xestospongia sponges. The Journal of organic chemistry66(9), 3246-3248. Article |
  • Heralde Iii, F. M., Kantor, Y. I., Astilla, M. A. Q., Lluisma, A. O., Geronimo, R., Aliño, P. M., Watkin, M., Showers-Corneli, P., Olivera, B. M., Santos, A. D.,  & Concepcion, G. P. (2010). The Indo-Pacific Gemmula species in the subfamily Turrinae: aspects of field distribution, molecular phylogeny, radular anatomy and feeding ecology. Philippine science letters3(1). | Article |
  • David, M. P. C., Concepcion, G. P., & Padlan, E. A. (2010). Using simple artificial intelligence methods for predicting amyloidogenesis in antibodies. BMC bioinformatics11(1), 1. Article |
  • Concepcion, G. P., & Padlan, E. A. (2009). Do prions aggregate in response to electrical stimulation and does this play a role in long-term memory?. Bioscience Hypotheses2(1), 24-26. Article |
  • Seronay, R. A., Fedosov, A. E., Astilla, M. A. Q., Watkins, M., Saguil, N., Heralde, F. M., Tagaro, S., Poppe, G. T., Aliño, P. M., Kantor, Y. I., Concepcion, G. P.,  & Olivera, B. M. (2010). Accessing novel Conoidean venoms: Biodiverse lumun-lumun marine communities, an untapped biological and toxinological resource. Toxicon56(7), 1257-1266.Article |
  • Concepcion, G. P., & Padlan, E. A. (2010). Does the electrical activity of neurons contribute to the pathogenesis of Alzheimer’s Disease?. Medical hypotheses74(1), 27-28.Article |
  • McCulloch, M. W., Bugni, T. S., Concepcion, G. P., Coombs, G. S., Harper, M. K., Kaur, S., Mangalindan, G. C., Mutizwa, M. M., Veltri, C. A., Virship, D. M., & Ireland, C. M. (2009). Carteriosulfonic acids A− C, GSK-3β inhibitors from a Carteriospongia spJournal of natural products,72(9), 1651-1656. Article |
  • Peraud, O., Biggs, J. S., Hughen, R. W., Light, A. R., Concepcion, G. P., Olivera, B. M., & Schmidt, E. W. (2009). Microhabitats within venomous cone snails contain diverse actinobacteria. Applied and environmental microbiology75(21), 6820-6826.Article |
  • Whitson, E. L., Bugni, T. S., Chockalingam, P. S., Concepcion, G. P., Feng, X., Jin, G., Harper, M. K., Mangalinda, G. C., McDonald, L. A., Ireland, C. M., & Ireland, C. M. (2009). Fibrosterol sulfates from the Philippine sponge Lissodendoryx (Acanthodoryxfibrosa: sterol dimers that inhibit PKCζ. The Journal of organic chemistry74(16), 5902-5908. Article |
  • Mazahery, A. R. F., Dator, R. P., Concepcion, G. P., & Jacinto, S. D. (2009). Murihexocin C from the leaves of Annona squamosa Linn. induces apoptosis in human colon carcinoma Col 2 cell line. Philippine Agricultural Scientist92(2), 122-132.Article |
  • Heralde III, F. M., Watkins, M., Ownby, J. P., Bandyopadhyay, P. K., Santos, A. D., Concepcion, G. P., & Olivera, B. M. (2007). Molecular phylogeny of some Indo-Pacific genera in the subfamily Turrinae H. Adams and A. Adams, 1853 (1838)(Gastropoda: Neogastropoda). Nautilus121(3), 131-138. | Article |
  • Marshall, K. M., Andjelic, C. D., Tasdemir, D., Concepcion, G. P., Ireland, C. M., & Barrows, L. R. (2009). Deoxyamphimedine, a pyridoacridine alkaloid, damages DNA via the production of reactive oxygen species. Marine drugs7(2), 196-209.Article |
  • Amor, E. C., Villaseñor, I. M., Antemano, R., Perveen, Z., Concepcion, G. P., & Choudhary, M. I. (2007). Cytotoxic C-methylated chalcones from Syzygium samarangensePharmaceutical Biology45(10), 777-783.Article |
  • Whitson, E. L., Bugni, T. S., Chockalingam, P. S., Concepcion, G. P., Harper, M. K., He, M., Hooper, J. N. A., Mangalindan, G. C., Ritacco, F., & Ireland, C. M. (2008). Spheciosterol sulfates, PKCζ inhibitors from a Philippine sponge Spheciospongia spJournal of natural products71(7), 1213-1217.Article |
  • Concepcion, G. P. (2008, June). Biological structures, interactions, function and behavior: Research opportunities for physicists. In Stochastic and Quantum Dynamics of Biomolecular Systems: Proceedings of the 5th Jagna International Workshop (Vol. 1021, No. 1, pp. 121-138). AIP Publishing.Article |
  • Heralde, F. M., Imperial, J., Bandyopadhyay, P. K., Olivera, B. M., Concepcion, G. P., & Santos, A. D. (2008). A rapidly diverging superfamily of peptide toxins in venomous Gemmula species. Toxicon51(5), 890-897.Article |
  • Punzalan, G. A. N., Concepcion, G. P., Dator, R. P., Mazahery, A., & Jacinto, S. D. (2008). P7 Flavonoid-positive plant fractions yield a potent inducer of promyelocytic leukemia cell differentiation with no enzyme inhibitory action within the XO system. European Journal of Cancer Supplements6(3), 43. | Article |
  • Sertan-de Guzman, A. A., Predicala, R. Z., Bernardo, E. B., Neilan, B. A., Elardo, S. P., Mangalindan, G. C., Tasdemir, D., Ireland, C. M., & Concepcion, G. P. (2007). Pseudovibrio denitrificans strain Z143-1, a heptylprodigiosin-producing bacterium isolated from a Philippine tunicate. FEMS microbiology letters,277(2), 188-196.Article |
  • David, M. P. C., Asprer, J. J. T., Ibana, J. S. A., Concepcion, G. P., & Padlan, E. A. (2007). A study of the structural correlates of affinity maturation: antibody affinity as a function of chemical interactions, structural plasticity and stability. Molecular immunology44(6), 1342-1351.Article |

Students:

Ph.D. Students

Azcuna, Miguel Enrique


Graduated Advisees (past 10 years):

MS Students 

                             Mary Anne Astilla-Ammon                                                                                                                                             

                               Thesis: Isolation, Anti-Microbial Activity and Localization of Marine Bacteria in Tissue of Conus rolani and Conus tribblei, 2011

                              Francis Arnaldo                                                                                                                                                                   

                               Thesis: Regulation of NA+, K+ - Atpase by D1- like Dopamine Receptors in the osmoregulatory gills of the blue crab, Callinectes sapidus,                                    2007

                               Glory Ranches                                                                                                                                                                        

                               Thesis: The marine metabolite Heptylprodisiosin: bioactivity and apoptotic mechanism of action in leukemic and other cancer cells, 2007

                               Aileen De Leon (co-adviser)                                                                                                                                          

                               Thesis: Development and evaluation of iodine-labeled analogs of u-conotoxin GIIIA for receptor binding assay of paralytic shellfish                                            poisons, 2009      

 

Neda Barghi (co-adviser)


Thesis: Investigating the evolution, diversification and expression of  conotoxins through comparative transcriptomics and genomics of                   closely related Conus species, 2014  


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