Gisela P. Concepcion, Ph.D.
Professor 
Academician of the National Academy of Science and Technology (NAST)


Education:
Ph.D. Chemistry
University of the Philippines, Diliman 

Research Interests: 
Marine Natural Products, Biochemistry, Development of Bioscreening Methods 

Selected Publications:
  • Billones, J. B., Carrillo, M. C. O., Organo, V. G., Macalino, S. J. Y., Sy, J. B. A., Emnacen, I. A., Clavio, N. A. B, & Concepcion, G. P. (2016). Toward antituberculosis drugs: In silico screening of synthetic compounds against Mycobacterium tuberculosis L,D-transpeptidase 2. Drug design, development and therapy, 10, 1147.  | Article |
  • Barghi, N., Concepcion, G. P., Olivera, B. M., & Lluisma, A. O. (2015). Characterization of the complete mitochondrial genome of Conus tribblei Walls, 1977. Mitochondrial DNA, 1-2. Article |
  • Barghi, N., Concepcion, G. P., Olivera, B. M., & Lluisma, A. O. (2015). Structural features of conopeptide genes inferred from partial sequences of the Conus tribblei genome. Molecular Genetics and Genomics, 1-12. Article |
  • Barghi, N., Concepcion, G. P., Olivera, B. M., & Lluisma, A. O. (2015). Comparison of the venom peptides and their expression in closely related Conus species: insights into adaptive post-speciation evolution of Conus exogenomes. Genome biology and evolution7(6), 1797-1814. Article |
  • Barghi, N., Concepcion, G. P., Olivera, B. M., & Lluisma, A. O. (2015). High conopeptide diversity in Conus tribblei revealed through analysis of venom duct transcriptome using two high-throughput sequencing platforms. Marine Biotechnology17(1), 81-98. Article |
  • Jacinto, M. P. V., Flores, M. S., Lin, Z., Concepcion, G. P., Schmidt, E. W., Faulkner, S., & Villaraza, A. J. L. (2014). Synthesis and bioactivity of nobilamide B. RSC Adv.4(71), 37609-37612. Article |
  • Arnaldo, F. B., Van Anthony, M. V., Konkalmatt, P. R., Owens, S. A., Asico, L. D., Jones, J. E., Yang, J., Lovett, D.L., Armando, I., Jose, P.A., & Concepcion, G. P. (2014). D1-like dopamine receptors downregulate Na+-K+-ATPase activity and increase cAMP production in the posterior gills of the blue crab Callinectes sapidusAmerican Journal of Physiology-Regulatory, Integrative and Comparative Physiology307(6), R634-R642. Article |
  • Imperial, J. S., Cabang, A. B., Song, J., Raghuraman, S., Gajewiak, J., Watkins, M. Showers-Corneli, P., Fedosov, A., Concepcion, G.P., Terlai, H., Teichert, R. W., & Olivera, B.M. (2014). A family of excitatory peptide toxins from venomous crassispirine snails: Using constellation pharmacology to assess bioactivity. Toxicon89, 45-54. Article |
  • Concepcion, G. P., Anas, A. R. J., & Azcuna, M. A. (2014). Anticancer compounds from Philippine marine organisms act on major pathways in cancer. Phil. Sci. Lett7, 207-227. Article |
  • Lin, Z., Zachariah, M. M., Marett, L., Hughen, R. W., Teichert, R. W., Concepcion, G. P., Haygood, M.G., Olivera, B.M., Light, A.R., & Schmidt, E. W. (2014). Griseorhodins D–F, neuroactive intermediates and end products of post-PKS tailoring modification in griseorhodin biosynthesis. Journal of natural products77(5), 1224-1230.Article |
  • Altamia, M. A., Wood, N., Fung, J. M., Dedrick, S., Linton, E. W., Concepcion, G. P., Haygood, M.G. & Distel, D. L. (2014). Genetic differentiation among isolates of Teredinibacter turnerae, a widely occurring intracellular endosymbiont of shipworms. Molecular ecology23(6), 1418-1432. Article |
  • Molina, J., Hazzouri, K. M., Nickrent, D., Geisler, M., Meyer, R. S., Pentony, M. M., Flowers, J.M., Pelser, P., Barcelona, J., Inovejas, S.A., Uy, I. Yuan, W., Wilkins, O., Michel, C., Locklear, S., Concepcion, G.P., & Purugganan, M.D. (2014). Possible loss of the chloroplast genome in the parasitic flowering plant Rafflesia lagascae (Rafflesiaceae). Molecular biology and evolution, msu051. Article |
  • Lin, Z., Koch, M., Pond, C. D., Mabeza, G., Seronay, R. A., Concepcion, G. P., Barrows, L.R., Olivera, B.M., & Schmidt, E. W. (2014). Structure and activity of lobophorins from a turrid mollusk-associated Streptomyces sp. The Journal of antibiotics67(1), 121-126. Article |
  • Lin, Z., Marett, L., Hughen, R. W., Flores, M., Forteza, I., Ammon, M. A., Concepcion, G.P., Espino, S., Olivera B.M., Rosenberg, G., Haygood, M. G., Light, A.R., & Schmidt, E.W. (2013). Neuroactive diol and acyloin metabolites from cone snail-associated bacteria. Bioorganic & medicinal chemistry letters,23(17), 4867-4869. Article |
  • Lin, Z., Torres, J. P., Ammon, M. A., Marett, L., Teichert, R. W., Reilly, C. A., Kwan, J.C., Highen, R.W., Flores, M., Tianero, M.D., Peraud, O., Cox, J.E., Light, A.R., Villaraza, A.J.L., Haygood, M.G., Concepcion, G.P., Olivera, B.M., & Schmidt, E.W. (2013). A bacterial source for mollusk pyrone polyketides. Chemistry & biology20(1), 73-81. Article |
  • Elshahawi, S. I., Trindade-Silva, A. E., Hanora, A., Han, A. W., Flores, M. S., Vizzoni, V., Schrago, C.G., Soares, C.A., Concepcion, G.P., Distel, D.L., Schmidt, E. W.,  Haygood, M. G. (2013). Boronated tartrolon antibiotic produced by symbiotic cellulose-degrading bacteria in shipworm gills. Proceedings of the National Academy of Sciences110(4), E295-E304. Article |
  • Betcher, M. A., Fung, J. M., Han, A. W., O’Connor, R., Seronay, R., Concepcion, G. P., Distel, D. L., & Haygood, M. G. (2012). Microbial distribution and abundance in the digestive system of five shipworm species (Bivalvia: Teredinidae). PLoS One7(9), e45309.Article |
  • Tatsukawa, M., Punzalan, L. L. C., Magpantay, H. D., Villasenor, I. M., Concepcion, G. P., Suwanborirux, K. Yokoya, M., Saito, N. (2012). Chemistry of renieramycins. Part 13: Isolation and structure of stabilized renieramycin type derivatives, renieramycins W–Y, from Philippine blue sponge Xestospongia sp., pretreated with potassium cyanide. Tetrahedron68(36), 7422-7428. Article |
  • Olivera, B. M., Watkins, M., Bandyopadhyay, P., Imperial, J. S., de la Cotera, E. P. H., Aguilar, M. B., Vera, E. L., Concepcion, G. P., & Lluisma, A. (2012). Adaptive radiation of venomous marine snail lineages and the accelerated evolution of venom peptide genes. Annals of the New York Academy of Sciences1267(1), 61-70. Article |
  • Lin, Z., Flores, M., Forteza, I., Henriksen, N. M., Concepcion, G. P., Rosenberg, G., Haygood, M. G., Olivera, B. M., Light, A. R., Cheatham, T. E., & Schmidt, E. W. (2012). Totopotensamides, polyketide–cyclic peptide hybrids from a mollusk-associated bacterium Streptomyces spJournal of natural products75(4), 644-649. Article |
  • Cabang, A. B., Imperial, J. S., Gajewiak, J., Watkins, M., Corneli, P. S., Olivera, B. M., & Concepcion, G. P. (2011). Characterization of a venom peptide from a crassispirid gastropod. Toxicon58(8), 672-680. Article |
  • Lin, Z., Reilly, C. A., Antemano, R., Hughen, R. W., Marett, L., Concepcion, G. P., Haygood, M. G., Olivera, B. M., Light, A.,  & Schmidt, E. W. (2011). Nobilamides A–H, long-acting transient receptor potential vanilloid-1 (TRPV1) antagonists from mollusk-associated bacteria. Journal of medicinal chemistry54(11), 3746-3755. Article |
  • Fedosov, A., Watkins, M., Heralde, F. M., Corneli, P. S., Concepcion, G. P., & Olivera, B. M. (2011). Phylogeny of the genus Turris: Correlating molecular data with radular anatomy and shell morphology. Molecular phylogenetics and evolution59(2), 263-270.Article |
  • Yu, P., Han, W., Van Anthony, M. V., Li, H., Arnaldo, F. B., Concepcion, G. P., Felder, R. A., Quinn, M. T., & Jose, P. A. (2011). Dopamine D 1 receptor-mediated inhibition of NADPH oxidase activity in human kidney cells occurs via protein kinase A–protein kinase C cross talk. Free Radical Biology and Medicine50(7), 832-840. Article |
  • Lin, Z., Antemano, R. R., Hughen, R. W., Tianero, M. D. B., Peraud, O., Haygood, M. G., Concepcion, G. P., Olivera, B. M., Light, A., & Schmidt, E. W. (2010). Pulicatins A− E, neuroactive thiazoline metabolites from cone snail-associated bacteria. Journal of natural products73(11), 1922-1926.Article |
  • Coombs, G. S., Yu, J., Canning, C. A., Veltri, C. A., Covey, T. M., Cheong, J. K., Utomo, V., Banerjee, N., Zhang, Z. H., Jadulco, R. C., Concepcion, G. P., Bugni, T. S., Harper, M. K., Mihalek, I., Jones, C. M., Ireland, C. M., & Virshup, D. M. (2010). WLS-dependent secretion of WNT3A requires Ser209 acylation and vacuolar acidification. Journal of cell science,123(19), 3357-3367.Article |
  • Tasdemir, D., Marshall, K. M., Mangalindan, G. C., Concepcion, G. P., Barrows, L. R., Harper, M. K., & Ireland, C. M. (2001). Deoxyamphimedine, a new pyridoacridine alkaloid from two tropical Xestospongia sponges. The Journal of organic chemistry66(9), 3246-3248. Article |
  • Heralde Iii, F. M., Kantor, Y. I., Astilla, M. A. Q., Lluisma, A. O., Geronimo, R., Aliño, P. M., Watkin, M., Showers-Corneli, P., Olivera, B. M., Santos, A. D.,  & Concepcion, G. P. (2010). The Indo-Pacific Gemmula species in the subfamily Turrinae: aspects of field distribution, molecular phylogeny, radular anatomy and feeding ecology. Philippine science letters3(1). | Article |
  • David, M. P. C., Concepcion, G. P., & Padlan, E. A. (2010). Using simple artificial intelligence methods for predicting amyloidogenesis in antibodies. BMC bioinformatics11(1), 1. Article |
  • Concepcion, G. P., & Padlan, E. A. (2009). Do prions aggregate in response to electrical stimulation and does this play a role in long-term memory?. Bioscience Hypotheses2(1), 24-26. Article |
  • Seronay, R. A., Fedosov, A. E., Astilla, M. A. Q., Watkins, M., Saguil, N., Heralde, F. M., Tagaro, S., Poppe, G. T., Aliño, P. M., Kantor, Y. I., Concepcion, G. P.,  & Olivera, B. M. (2010). Accessing novel Conoidean venoms: Biodiverse lumun-lumun marine communities, an untapped biological and toxinological resource. Toxicon56(7), 1257-1266.Article |
  • Concepcion, G. P., & Padlan, E. A. (2010). Does the electrical activity of neurons contribute to the pathogenesis of Alzheimer’s Disease?. Medical hypotheses74(1), 27-28.Article |
  • McCulloch, M. W., Bugni, T. S., Concepcion, G. P., Coombs, G. S., Harper, M. K., Kaur, S., Mangalindan, G. C., Mutizwa, M. M., Veltri, C. A., Virship, D. M., & Ireland, C. M. (2009). Carteriosulfonic acids A− C, GSK-3β inhibitors from a Carteriospongia spJournal of natural products,72(9), 1651-1656. Article |
  • Peraud, O., Biggs, J. S., Hughen, R. W., Light, A. R., Concepcion, G. P., Olivera, B. M., & Schmidt, E. W. (2009). Microhabitats within venomous cone snails contain diverse actinobacteria. Applied and environmental microbiology75(21), 6820-6826.Article |
  • Whitson, E. L., Bugni, T. S., Chockalingam, P. S., Concepcion, G. P., Feng, X., Jin, G., Harper, M. K., Mangalinda, G. C., McDonald, L. A., Ireland, C. M., & Ireland, C. M. (2009). Fibrosterol sulfates from the Philippine sponge Lissodendoryx (Acanthodoryxfibrosa: sterol dimers that inhibit PKCζ. The Journal of organic chemistry74(16), 5902-5908. Article |
  • Mazahery, A. R. F., Dator, R. P., Concepcion, G. P., & Jacinto, S. D. (2009). Murihexocin C from the leaves of Annona squamosa Linn. induces apoptosis in human colon carcinoma Col 2 cell line. Philippine Agricultural Scientist92(2), 122-132.Article |
  • Heralde III, F. M., Watkins, M., Ownby, J. P., Bandyopadhyay, P. K., Santos, A. D., Concepcion, G. P., & Olivera, B. M. (2007). Molecular phylogeny of some Indo-Pacific genera in the subfamily Turrinae H. Adams and A. Adams, 1853 (1838)(Gastropoda: Neogastropoda). Nautilus121(3), 131-138. | Article |
  • Marshall, K. M., Andjelic, C. D., Tasdemir, D., Concepcion, G. P., Ireland, C. M., & Barrows, L. R. (2009). Deoxyamphimedine, a pyridoacridine alkaloid, damages DNA via the production of reactive oxygen species. Marine drugs7(2), 196-209.Article |
  • Amor, E. C., Villaseñor, I. M., Antemano, R., Perveen, Z., Concepcion, G. P., & Choudhary, M. I. (2007). Cytotoxic C-methylated chalcones from Syzygium samarangensePharmaceutical Biology45(10), 777-783.Article |
  • Whitson, E. L., Bugni, T. S., Chockalingam, P. S., Concepcion, G. P., Harper, M. K., He, M., Hooper, J. N. A., Mangalindan, G. C., Ritacco, F., & Ireland, C. M. (2008). Spheciosterol sulfates, PKCζ inhibitors from a Philippine sponge Spheciospongia spJournal of natural products71(7), 1213-1217.Article |
  • Concepcion, G. P. (2008, June). Biological structures, interactions, function and behavior: Research opportunities for physicists. In Stochastic and Quantum Dynamics of Biomolecular Systems: Proceedings of the 5th Jagna International Workshop (Vol. 1021, No. 1, pp. 121-138). AIP Publishing.Article |
  • Heralde, F. M., Imperial, J., Bandyopadhyay, P. K., Olivera, B. M., Concepcion, G. P., & Santos, A. D. (2008). A rapidly diverging superfamily of peptide toxins in venomous Gemmula species. Toxicon51(5), 890-897.Article |
  • Punzalan, G. A. N., Concepcion, G. P., Dator, R. P., Mazahery, A., & Jacinto, S. D. (2008). P7 Flavonoid-positive plant fractions yield a potent inducer of promyelocytic leukemia cell differentiation with no enzyme inhibitory action within the XO system. European Journal of Cancer Supplements6(3), 43. | Article |
  • Sertan-de Guzman, A. A., Predicala, R. Z., Bernardo, E. B., Neilan, B. A., Elardo, S. P., Mangalindan, G. C., Tasdemir, D., Ireland, C. M., & Concepcion, G. P. (2007). Pseudovibrio denitrificans strain Z143-1, a heptylprodigiosin-producing bacterium isolated from a Philippine tunicate. FEMS microbiology letters,277(2), 188-196.Article |
  • David, M. P. C., Asprer, J. J. T., Ibana, J. S. A., Concepcion, G. P., & Padlan, E. A. (2007). A study of the structural correlates of affinity maturation: antibody affinity as a function of chemical interactions, structural plasticity and stability. Molecular immunology44(6), 1342-1351.Article |

Students:

Ph.D. Students

Azcuna, Miguel Enrique


Graduated Advisees (past 10 years):

MS Students 

                              Mary Anne Astilla-Ammon                                                                                                                                             Thesis: Isolation, Anti-Microbial Activity and Localization of Marine Bacteria in                                           Tissue of Conus rolani and Conus tribblei, 2011

                              Francis Arnaldo                                                                                                                                                                   Thesis: Regulation of NA+, K+ - Atpase by D1- like Dopamine Receptors in                                                       the osmoregulatory gills of the blue crab, Callinectes sapidus, 2007

                               Glory Ranches                                                                                                                                                                        Thesis: The marine metabolite Heptylprodisiosin: bioactivity and                                                                        apoptotic mechanism of action in leukemic and other cancer cells, 2007

                               Aileen De Leon (co-adviser)                                                                                                                                          Thesis: Development and evaluation of iodine-labeled analogs of u-conotoxin                                                  GIIIA for receptor binding assay of paralytic shellfish poisons, 2009      

 

Neda Barghi (co-adviser)

Thesis: Investigating the evolution, diversification and expression of                                                   conotoxins through comparative transcriptomics and genomics of closely related                           Conus species, 2014  


Links/Website: